Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors

Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors

In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a-5f) showed the most potent mushroom tyrosinase inhibition (IC₅₀ values in the range of 4.39 ± 0.76-1.71 ± 0.49 µM), compara...

Isoprenylated Phenolic Compounds from Morus macroura as Potent Tyrosinase Inhibitors.

Three new Diels-Alder adducts, macrourins E - G (1: -3: ), one new 2-arylbenzofuran, macrourin H (4: ), and eight known Diels-Alder adducts (5: -12: ) were isolated from Morus macroura. Their structures were elucidated through extensive analysis of spectroscopic data. The 1H NMR and ECD trends in the determination of the configurations of these Diels-Alder adducts were summarized. The tyrosinas...

Natural peptides and proteins: potent tyrosinase inhibitors

Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...

new pantacyclic tacrines as potent acetylcholinesterase inhibitors

Conventional Organic Solvents and Ionic Liquid Mediated Synthesis of New Azomethine Compounds as Potent Cholinesterase Inhibitors Basma M. Abd Razik Universiti Sains Malaysia 2016 Conventional Organic Solvents and Ionic Liquid Mediated Synthesis of New Azomethine Compounds as Potent Cholinesterase Inhibitors

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